Kapanlagi.com - What if a single pill or serum could change a person's destiny in a matter of seconds? This concept serves as the backdrop for various best science fiction films that highlight how experimental drugs and serums can transform humans.
Some become younger, geniuses, or even terrifying monsters. These science fiction movie recommendations offer thrilling storytelling experiences that are surprising. They not only present thrilling action but also philosophical questions about the limits of human power and the consequences of scientific experiments.
In this article, we discuss five of the best science fiction films that focus on the discovery of new serums or drugs. Curious about what the best science fiction movie recommendations are regarding serum and drug discoveries? Check out the full recommendations here, KLovers.
1. THE SUBSTANCE

Poster THE SUBSTANCE (credit: imdb.com)
Rating | 7.3/10 IMDb |
Duration | 2 hours 21 minutes |
Streaming | Prime Video |
Cast | Demi Moore, Margaret Qualley, Dennis Quaid |
One of the best science fiction film recommendations is titled THE SUBSTANCE. This film was released in 2024 and features the genres of sci-fi, dark comedy, horror, and drama. The film THE SUBSTANCE has made it to the top ranks after successfully receiving various nominations and prestigious awards such as the Toronto International Film Festival, Cannes Film Festival, the 2025 Academy Awards, and others.
The synopsis of THE SUBSTANCE tells the story of a celebrity who is obsessed with becoming more beautiful with a youthful appearance. As she ages, she experiences skin aging. To change her appearance to look more beautiful, she becomes interested in using a serum that can transform her appearance into a youthful one. The serum can cover her original appearance. Although it initially goes smoothly, the effects of using the serum begin to destroy Elizabeth's life.
2. YASHODA

YASHODA Poster (credit: imdb.com)
Rating | 6.5/10 IMDb |
Duration | 2 hours 15 minutes |
Streaming | Prime Video |
Cast | Samantha Ruth Prabhu, Unni Mukundan, Varalaxmi Sarathkumar |
The next recommendation for the best science fiction film is YASHODA. This film from India was released in 2022 and falls under the sci-fi genre. The synopsis of YASHODA highlights a young woman who decides to become a surrogate mother. She accepts the offer and is paid a high fee.
However, to participate in the program, Yashoda is taken to a secret location. There, many women are becoming surrogate mothers. Although things initially go smoothly, Yashoda discovers anomalies in the secret place. She begins to uncover dark experiments that use women's bodies for DNA-based cosmetic products. The serum, it turns out, can make a person's appearance more youthful.
3. PROJECT POWER

PROJECT POWER Poster (credit: imdb.com)
Rating | 6.0/10 IMDb |
Duration | 1 hour 53 minutes |
Released | Netflix |
Cast | Jamie Foxx, Joseph Gordon-Levitt, Dominique Fishback |
PROJECT POWER is among the best science fiction films not to be missed. This film was released in 2020 and features action, sci-fi, thriller, and superhero genres. The synopsis of PROJECT POWER tells the story of a group of people trying to dismantle a network of mysterious drug dealers.
The pill apparently gives someone superpowers. However, these superpowers do not last permanently as they are time-limited. Similarly, the effects can vary. They work together to uncover the case.
4. I AM LEGEND

I AM LEGEND Poster (credit: imdb.com)
Rating | 7.2/10 IMDb |
Duration | 1 hour 41 minutes |
Streaming | Prime Video |
Cast | Will Smith, Alice Braga |
I AM LEGEND is recommended as one of the best science fiction films released in 2007. Although it is an older film, the storyline is still very exciting. The synopsis of I AM LEGEND tells the story of a serum that ends up destroying the world. Who would have thought that this new drug serum would turn humans into the undead or zombies? Initially, the experiment was conducted to find a cure for cancer, but it instead became a new threat to humanity.
The situation becomes increasingly tense as many people turn into terrifying zombies. The only surviving scientist tries to stop the outbreak by finding an antidote through his experiments. However, the journey is not as easy as it seems.
5. LIMITLESS

LIMITLESS Poster (credit: imdb.com)
Rating | 7.4/10 IMDb |
Duration | 1 hour 45 minutes |
Streaming | Prime Video |
Cast | Bradley Cooper, Robert De Niro, Abbie Cornish |
The best science fiction movie recommendation titled LIMITLESS should not be missed. This film highlights a writer named Eddie Morra. He discovers a drug called NZT-48. Not just an ordinary drug, this pill can enhance brain capabilities. Who would have thought, Eddie truly reaps the benefits of it.
Without waiting long, Eddie uses his abilities to gain a lot of advantages. Including an increase in income. However, Eddie experiences side effects from using the drug. Not to mention, he has to deal with various parties trying to exploit him.
That is the best science fiction movie recommendation about the discovery of a new serum and drug. Follow the latest celebrity news only at Kapanlagi.com. If not now, when?
(kpl/nlw)
Disclaimer: This translation from Bahasa Indonesia to English has been generated by Artificial Intelligence.